Zembrin

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ZEMB-SCEN04-0018(v.1.0)

The Impact of Stress on Mental Wellness and Cognition

While modern medicine often focuses on mental illness, it is time for us to focus on brain health. Declining cognition, poor mood, stress and anxiety are the areas of high concern. The relationship between these conditions is deeply interconnected, with stress and anxiety decreasing cognitive function, learning, and memory¹. Conversely, cognitive difficulties can also contribute to increased stress and anxiety.

Introducing Zembrin®: A Natural Solution

Zembrin®, a botanical ingredient originating from Sceletium plants in South Africa, offers a natural solution to these pressing brain concerns. For centuries, the San and Khoi people of South Africa have consumed Sceletium plants, the source of Zembrin®, for its stress-relieving and mood-enhancing properties. Modern medicine has validated these traditional uses through eight pilot double-blind, placebo-controlled clinical studies.

There are multiple benefits to using a brain health product that contains Zembrin®

The studies confirm that:

• Zembrin® improves cognitive memory², slowing down cognitive decline.
• Zembrin® improves processing speed³, improving the brain fluency. Helping you to receive, understand and respond to information.
• Zembrin® improves cognitive flexibility⁴, which boosts the ability to adapt behaviour and thinking in response to the environment.
• Zembrin® improves complex attention⁵, thereby boosting attention and focus.
• Zembrin® improves psychomotor speed⁶, boosting speed of thinking and/or integration of speed of thinking with rapid motor actions.
• Zembrin® improves executive function⁷, boosting working memory, attention control, response inhibition and concept formulation.
• Zembrin® enhances mood⁸.
• Zembrin® reduces anxiety⁹.

Why Choose Zembrin?

Zembrin® is produced using efficient extraction technology, resulting in a low-dose, potent, and stable ingredient. Its neutral chemistry makes it adaptable for use in various consumer products, including beverages, supplements, and food-related products. As a natural, evidence-based solution, Zembrin® is an excellent addition to brain health products.

The Sceletium plants used in the production of Zembrin® is cultivated exclusively for HG&H Pharmaceuticals (Pty)Ltd, the proprietary owners of Zembrin® and no other. Due to commercialisation, it is not sustainable to conduct wild harvesting. Realising this, HG&H Pharmaceuticals (Pty)Ltd committed to using only cultivated plant material in the production of Zembrin® to avoid depleting wild plant stocks and ensure consistent product quality.

A royalty is paid to the South African San Council on all Zembrin® sold, in recognition of the contribution of their indigenous knowledge to the development of Zembrin®.

Conclusion

In today’s world, where stress and mental wellness struggles are prevalent, Zembrin® offers a natural, effective solution. By incorporating Zembrin® into brain health products, individuals can improve their cognitive function, wellbeing, and resilience. Embracing this ancient botanical ingredient can help us move forward in addressing modern brain health concerns.

References:

1. Yaribeygi H, Panahi Y, Saraei H, Johnson TP, Sahebkar A. The impact of stress on body function. A review. EXCLI J, 2017; 16:1057-1072. Published 2017 Jul 21 doi10.17179/excli2017- 480.
2. Chiu S, et al. Proof-of-Concept Randomized Controlled Study of Cognition Effects of the Proprietary Extract Sceletium tortuosum (Zembrin) Targeting Phosphodiesterase-4 in Cognitively Healthy Subjects: Implications for Alzheimer’s Dementia. Evidence-based complementary and alternative medicine. 2014:682014.
3.  Wightman E, et al. Psychological effects of 8 weeks supplementation with Sceletium tortuosum extract (Zembrin™): a randomised, double blind, placebo-controlled, parallel-groups. Performance and Nutrition Research Centre, Northumbria University. Protocol No. 61CC1.
4. Chiu S, et al. Proof-of-Concept Randomized Controlled Study of Cognition Effects of the Proprietary Extract Sceletium tortuosum (Zembrin) Targeting Phosphodiesterase-4 in Cognitively Healthy Subjects: Implications for Alzheimer’s Dementia. Evidence-based complementary and alternative medicine. 2014:682014.
5.  Dimpfel W, et al. Psychophysiological Effects of Zembrin® Using Quantitative EEG Source Density in Combination with Eye-Tracking in 60 Healthy Subjects. A Double-Blind, Randomized, Placebo-Controlled, 3-Armed Study with Parallel Design. Neuroscience and Medicine. 2016;7:114-132.
6. Chiu S, et al. Proof-of-Concept Randomized Controlled Study of Cognition Effects of the Proprietary Extract Sceletium tortuosum (Zembrin) Targeting Phosphodiesterase-4 in Cognitively Healthy Subjects: Implications for Alzheimer’s Dementia. Evidence-based complementary and alternative medicine. 2014:682014.
7. Chiu S, et al. Proof-of-Concept Randomized Controlled Study of Cognition Effects of the Proprietary Extract Sceletium tortuosum (Zembrin) Targeting Phosphodiesterase-4 in Cognitively Healthy Subjects: Implications for Alzheimer’s Dementia. Evidence-based complementary and alternative medicine. 2014:682014.
8. Chiu S, et al. Proof-of-Concept Randomized Controlled Study of Cognition Effects of the Proprietary Extract Sceletium tortuosum (Zembrin) Targeting Phosphodiesterase-4 in Cognitively Healthy Subjects: Implications for Alzheimer’s Dementia. Evidence-based complementary and alternative medicine. 2014:682014.
9.  Terburg D, et al. Acute Effects of Sceletium tortuosum (Zembrin), a Dual 5-HT Reuptake and PDE4 Inhibitor, in the Human Amygdala and its Connection to the Hypothalamus. Neuropsychopharmacology. 2013;38:2708-2716.